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分子遗传学阅读文献：重组与副突变
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Finding a match-How do homologous sequences get together for recombination
Barzel A, Kupiec M. Finding a match: how do homologous sequences get together for recombination? Nat Rev Genet. 2008 Jan; 9 (1): 27-37.
Decades of research into homologous recombination have unravelled many of the details concerning the transfer of information between two homologous sequences. By contrast, the processes by which the interacting molecules initially colocalize are largely unknown. How can two homologous needles find each other in the genomic haystack? Is homologous pairing the result of a damage-induced homology search, or is it an enduring and general feature of the genomic architecture that facilitates homologous recombination whenever and wherever damage occurs? This Review presents the homologous-pairing enigma, delineates our current understanding of the process and offers guidelines for future research.
Recent advances in plant recombination
Li J, Hsia AP, Schnable PS. Recent advances in plant recombination. Curr Opin Plant Biol. 2007 Apr; 10 (2): 131-5. Epub 2007 Feb 8.
Recombination is an essential cellular process and a source of genetic diversity. Recent studies have demonstrated the effects of various factors (e.g. DNA sequence similarity and activation of transposons) on rates of recombination and the distribution of recombination breakpoints in plants. These studies have also provided detailed characterizations of interchromatid and interhomolog recombination events. New approaches offer the promise of achieving the long-awaited goal of gene targeting in plants.
Plant genome modification by homologous recombination
Hanin M, Paszkowski J. Plant genome modification by homologous recombination. Curr Opin Plant Biol. 2003 Apr; 6 (2): 157-62.
The mechanisms and frequencies of various types of homologous recombination (HR) have been studied in plants for several years. However, the application of techniques involving HR for precise genome modification is still not routine. The low frequency of HR remains the major obstacle but recent progress in gene targeting in Arabidopsis and rice, as well as accumulating knowledge on the regulation of recombination levels, is an encouraging sign of the further development of HR-based approaches for genome engineering in plants.
Recombination-an underappreciated factor in evolution of plant genomes
Gaut BS, Wright SI, Rizzon C, Dvorak J, Anderson LK. Recombination: an underappreciated factor in the evolution of plant genomes. Nat Rev Genet. 2007 Jan; 8 (1): 77-84.
Our knowledge of recombination rates and patterns in plants is far from being comprehensive. However, compelling evidence indicates a central role for recombination, through its influences on mutation and selection, in the evolution of plant genomes. Furthermore, recombination seems to be generally higher and more variable in plants than in animals, which could be one of the primary reasons for differences in genome lability between these two kingdoms. Much additional study of recombination in plants is needed to investigate these ideas further.
Genetics: paramutable possibilities
Soloway PD. Genetics: paramutable possibilities. Nature. 2006 May 25; 441 (7092): 413-4
Paramutation: an encounter leaving a lasting impression
Stam M, Mittelsten Scheid O. Paramutation: an encounter leaving a lasting impression. Trends Plant Sci. 2005 Jun; 10 (6): 283-90.
Paramutation is the result of heritable changes in gene expression that occur upon interaction between alleles. Whereas Mendelian rules, together with the concept of genetic transmission via the DNA sequence, can account for most inheritance in sexually propagating organisms, paramutation-like phenomena challenge the exclusiveness of Mendelian inheritance. Most paramutation-like phenomena have been observed in plants but there is increasing evidence for its occurrence in other organisms, including mammals. Our knowledge of the underlying mechanisms, which might involve RNA silencing, physical pairing of homologous chromosomal regions or both, is still limited. Here, we discuss the characteristics of different paramutation-like interactions in the light of arguments supporting each of these alternative mechanisms.
Paramutation and transgene silencing: A common responsive to invasive DNA?
Finding a match-How do homologous sequences get together for recombination
Recent advances in plant recombination
Plant genome modification by homologous recombination
Recombination-an underappreciated factor in evolution of plant genomes
Genetics-paramutable possibilities
Paramutation-an encounter leaving a lasting impression
Paramutation and transgene silencing-A common responsive to invasive DNA
From centiMorgans to base-pairs: homologous recombination in plants
https://blog.sciencenet.cn/blog-39731-36686.html
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