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夏宁邵教授研究论文被引用情况

已有 6250 次阅读 2010-9-1 09:29 |个人分类:科技评价|系统分类:论文交流| 引用, 夏宁邵

http://www.bjkw.gov.cn/n1143/n1240/n1390/n1811/8474415.html

我国戊肝疫苗研制取得重大突破

        戊型肝炎是主要的病毒性肝炎之一,国内外尚无疫苗。据估计全球有三分之一人口曾感染过戊型肝炎病毒。戊型肝炎症状与甲型肝炎类似,但病死率更高,症状更重,对孕妇、老年人和慢性肝病患者的危害尤烈,孕妇病死率高达20%。我国是戊型肝炎高流行区,近年来发病率持续上升。
  近期,由国家传染病诊断试剂与疫苗工程技术研究中心(厦门大学)、北京万泰生物药业股份有限公司、厦门万泰沧海生物技术有限公司等单位联合研制的戊型肝炎疫苗取得重大突破,三期临床研究证实戊肝疫苗安全有效,等待药监部门批准后即可迅速上市。相关研究成果近日在国际著名医学刊物《柳叶刀》上发表,并得到了美国疾病预防控制中心肝炎室主任Scott D Holmberg博士的高度评价,标志着我国在戊型肝炎疫苗研制方面已达到世界领先水平。
  我国研制的戊型肝炎疫苗,迄今已取得4项国内外授权发明专利,是我国少见的高度原创性生物药物之一,国家食品药品监督管理局将其纳入特殊审评程序,于今年8月19号召开了审批咨询会议。目前,国际主要疫苗跨国企业瑞士诺华公司、美国默克公司、法国赛诺菲-巴斯德公司、英国葛兰素史克公司均对合作开发该疫苗的国际市场表现出浓厚兴趣。

祝贺夏宁邵教授科研团队的重大科技成果发表。

http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(10)61030-6/abstract

Efficacy and safety of a recombinant hepatitis E vaccine in healthy adults: a large-scale, randomised, double-blind placebo-controlled, phase 3 trial

Feng-Cai Zhu MSc a, Prof Jun Zhang MD b, Xue-Feng Zhang MSc a, Cheng Zhou MD c, Zhong-Ze Wang MD d, Shou-Jie Huang MD b, Hua Wang MD a, Chang-Lin Yang BSc d, Han-Min Jiang BSc d, Jia-Ping Cai BSc d, Yi-Jun Wang BSc d, Xing Ai MSc a, Yue-Mei Hu MD a, Quan Tang MD a, Xin Yao MSc c, Qiang Yan MSc b, Yang-Ling Xian BSc e, Prof Ting Wu PhD b, Yi-Min Li MD e, Prof Ji Miao PhD b, Prof Mun-Hon Ng PhD b, Prof James Wai-Kuo Shih PhD b, Prof, Dr Ning-Shao Xia MD b Corresponding AuthorEmail Address

 

如有读者发现以下检索结果有误,请你在此网站核对:http://scholar.google.com/scholar?start=0&q=+Ning-Shao+Xia&hl=en&as_sdt=2000

ystwt.com [PDF]

… Wang, H Zhang, N Xia, G Peng, HY … - Journal of medical …, 2002 - interscience.wiley.com
You-Chun Wang,1,2 Hua-yuan Zhang,1 Ning-shao Xia,3 Geng Peng,4 Hai-Yun Lan,1 Hui
Zhuang,5 Yong-Hong Zhu,5 Shao-Wei Li,3 Ke-Gong Tian,6 Wen-Jie Gu,1 Jing-Xiang Lin,1 Xing
Wu,1 He-Min Li,1 and Tim J. Harrison2* 1National Institute for the Control of ...
Cited by 122 - Related articles - BL Direct - All 6 versions

 

wjgnet.com [PDF]… , M Li, T Cheng, SW Li, J Zhang, NS Xia - World Journal of …, 2003 - wjg.wjgnet.com
... Copyright © 2003 by The WJG Press ISSN 1007-9327 • VIRAL HEPATITIS • Oral
immunization of animals with transgenic cherry tomatillo expressing HBsAg Yi Gao, Ying
Ma, Mei Li, Tong Cheng, Shao-Wei Li, Jun Zhang, Ning-Shao Xia ...
Cited by 45 - Related articles - View as HTML - BL Direct - All 8 versions

 

wjgnet.com [PDF]… Lin, Y Gao, M Li, WX Luo, J Zhang, NS Xia - World Journal of …, 2003 - wjg.wjgnet.com
... Copyright © 2003 by The WJG Press ISSN 1007-9327 • VIRAL HEPATITIS • Expression of ORF2
partial gene of hepatitis E virus in tomatoes and immunoactivity of expression products Ying Ma,
Shun-Quan Lin, Yi Gao, Mei Li, Wen-Xin Luo, Jun Zhang, Ning-Shao Xia ...
Cited by 38 - Related articles - View as HTML - BL Direct - All 9 versions

 

wjgnet.com [PDF]… , YB Wang, M Chen, T Wu, J Zhang, NS Xia - World Journal of …, 2004 - wjg.wjgnet.com
... Copyright © 2004 by The WJG Press ISSN 1007-9327 • BASIC RESEARCH • A rapid and efficient
method to express target genes in mammalian cells by baculovirus Tong Cheng, Chen-Yu Xu,
Ying-Bin Wang, Min Chen, Ting Wu, Jun Zhang, Ning-Shao Xia ...
Cited by 32 - Related articles - View as HTML - BL Direct - All 7 versions

 

jbc.org [HTML]… , Y Gu, RS Liu, J Lin, YX Chen, MH Ng, NS Xia - Journal of Biological …, 2005 - ASBMB
The hepatitis E virus (HEV) capsid consists of a single structural protein, a portion of which is
engaged in isosahedral contact to form a basal shell, and another portion in dimeric contact to
form the homodimers protruding from the shell. Previous studies revealed that ...
Cited by 28 - Related articles - All 6 versions

 

NS Xia, WX Luo, J Zhang, XY Xie, HJ Yang, SW Li, … - Marine …, 2002 - Springer
Abstract: Studies of the bioluminescent mechanisms of jellyfish have been mainly confined to
one species, Aequorea victoria. We describe the luminescent system of another species, Aequorea
macrodactyla, which is commonly found in the warmer waters on the coastal region of ...
Cited by 18 - Related articles - BL Direct - All 3 versions

 

wjgnet.com [PDF]… , J Lin, YW Lin, ZH Zhang, J Zhang, NS Xia - World J …, 2004 - wjg.wjgnet.com
... BASIC RESEARCH • High-yield expression of recombinant SARS coronavirus
nucleocapsid protein in methylotrophic yeast Pichia pastoris Ru-Shi Liu, Kun-Yu Yang,
Jian Lin, Yi-Wei Lin, Zhi-Hong Zhang, Jun Zhang, Ning-Shao Xia ...
Cited by 12 - Related articles - View as HTML - All 7 versions

 

… -shun, LI Shao-wei, Z Jun, XIA Ning-shao - Chinese Journal of …, 2005 - en.cnki.com.cn
Genomic sequences of genotypes I, II, III and IV of hepatitis E virus were aligned and the conserved
region was selected for designing a set of reverse-transcription polymerase chain reaction
(RT-PCR) primers, which were denominated as E primers. The sensitivity of E primers ...
Cited by 10 - Related articles - Cached - All 2 versions
wjgnet.com [PDF]… , YB Wang, SW Li, HJ Yang, WX Luo, NS Xia - World Journal of …, 2004 - wjgnet.com
... VIRAL HEPATITIS • Selection of a peptide mimicking neutralization epitope of hepatitis
E virus with phage peptide display technology Ying Gu, Jun Zhang, Ying-Bing Wang,
Shao-Wei Li, Hai-Jie Yang, Wen-Xin Luo, Ning-Shao Xia ...
Cited b

[HTML]

… Zheng, Y Nong, QS Guo, J Zhang, MH Ng, NS Xia - 传染病的 …, 2006 - journal.shouxi.net
Genotype 4 hepatitis E virus (HEV) is the dominant cause of hepatitis E in the People's Republic
of China; swine are the principal reservoir. Our study was conducted in 8 rural communities of
southern China, where families keep pigs near their homes. Phylogenetic analysis ...

 

 

… GU, YLINJLIU Ru-Shi, XIA Ning-Shao - Chinese Journal of …, 2002 - en.cnki.com.cn
A fragment of hepatitis E virus open reading frame-2(ORF2), located from amino acid residues
394 to 604, was expressed in E.coli. The recombinant protein NE2 was found to form homodimer
mostly in SDS-PAGE, which can be dissociated to monomers when treated with urea, and ...

 

[PDF]

DY Tian, Y Chen, NS Xia - World Journal of Gastroenterology, 2006 - wjgnet.com
Hepatitis E is caused by infection with hepatitis E virus (HEV), which is a non-enveloped
single-stranded RNA virus. Just like hepatitis A virus (HAV), HEV is usually transmitted from
person-to-person via the fecal-oral route. Epidemic of hepatitis E has been found in ...

 

 

Y CHEN, DY TIAN, NS XIA - Chinese Journal of Digestive …, 2005 - ingentaconnect.com
... Epidemiology and genotypes of HEV in Wuhan. Authors: CHEN, Yan 1 ; TIAN, De Ying;
XIA, Ning Shao 2. Source: Chinese Journal of Digestive Diseases, Volume 6, Number 4,
November 2005 , pp. 182-188(7). Publisher: Blackwell Publishing. ...

 

[PDF]

… Li, BQ Guan, ZH Zhu, Y Gu, J Zhang, NS Xia - World J …, 2005 - wjg.wjgnet.com
Expression and immunoactivity of chimeric particulate antigens of ... Hai-Jie Yang, Min
Chen, Tong Cheng, Shui-Zhen He, Shao-Wei Li, Bao-Quan Guan, Zi -Heng Zhu, Ying Gu, Jun
Zhang, Ning-Shao Xia ... E-mail: wjg@wjgnet.com www.wjgnet.com

 

 

… Cheng, BQ Guan, SW Li, J Miao, J Zhang, NS Xia - Marine …, 2006 - Springer
As research progresses, fluorescent proteins useful for optical marking will evolve toward
brighter, monomeric forms that are more diverse in color. We previously reported a new fluorescent
protein from Aequorea macrodactyla, GFPxm, that exhibited many characteristics similar ...

 

… B Pan, Y Nong, SX Ge, J Xiong, JW Shih, MH Ng, N Xia - Vaccine, 2009 - Elsevier
Hepatitis E virus (HEV), a member of Hepevirus genus, is an RNA positive strand virus that resembles
calicivirus in respect of its morphology and organization of its 7.5 kb genome [1]. The virus is
consists of a single serotype and subdivided into four major genotypes, of which ...

 

 

… , Z Yu, X Jun-hui, Z Jun, XIA Ning-shao - Chinese Journal of …, 2007 - en.cnki.com.cn
In this study,a new combined enzyme immunoassay(NRAg ELISA) for detection of HBV PreS1
and core antigens which was highly consistent with serum HBV DNA test was established.The
serial serum dilution test indicated that the average sensitivity of the assay was 103.2 ...

 

 

… S Ou, C Lin, T Cheng, S Li, MH Ng, J Zhang, N Xia - Molecular …, 2007 - Elsevier
The candidate particulate hepatitis E vaccine, HEV 239, has been shown to be an efficacious
vaccine in primates, and clinical study to date shows it to be safe and immunogenic for
humans. The antigenicity of HEV 239 is virtually identical to its N-terminal 26 amino acids ...

Seroprevalence of hepatitis E virus infection, rural southern People's Republic of Chinashouxi.net [HTML]Cited by 36 - Related articles - Cached - All 9 versionsThe Study of Aggregate of the ORF2 Peptide of Hepatitis E Virus Expressed in Escherichia coli [J]Cited by 7 - Related articles - CachedSignificance of serum IgA in patients with acute hepatitis E virus infectionwjgnet.com [PDF]Cited by 8 - Related articles - View as HTML - BL Direct - All 8 versionsEpidemiology and genotypes of HEV in WuhanCited by 8 - Related articles - BL Direct - All 2 versionsExpression and immunoactivity of chimeric particulate antigens of receptor binding site-core antigen of hepatitis B viruswjgnet.com [PDF]Cited by 6 - Related articles - View as HTML - All 7 versionsVariants of green fluorescent protein GFPxmCited by 6 - Related articles - BL Direct - All 4 versionsConstruction and Application of an Escherichia coli High Effective Expression Vector with an Enhancer [J]LUOWXZJ YANG, HJLISW XIE, XYPSQ LI, … - CHINESE JOURNAL …, 2000 - en.cnki.com.cn
In this study,we constructed a high effective fusion expression vector in E.coli . This vector,pTO
T7,was characterized as: (1) an enhancer from tobacoo mosaic virus (TMV),Ω sequence,was
ligated in front of a T7 promoter in the regulatory sequence; (2) the multicloning sites ...
Cited by 8 - Related articles - CachedRandomized-controlled phase II clinical trial of a bacterially expressed recombinant hepatitis E vaccineCited by 9 - Related articles - All 5 versionsEstablishment of a New Combined Enzyme Immunoassay for Detection of HBV PreS1 and Core Antigens and the Consistency with HBV DNA Test [J]Cited by 4 - Related articles - Cached - All 2 versionsDifference of T cell and B cell activation in two homologous proteins with similar antigenicity but great distinct immunogenicityCited by 4 - Related articles - All 3 versions
The Establishment of Cellular Attachment Model for Hepatitis E Virus (HEV) and Its Application in the Identification of HEV Cellular Attachment Region [J]
… Ming-hui, M Ji, J ZHANG, XIA Ning-shao - Chinese Journal of …, 2006 - en.cnki.com.cn
We have previously expressed a recombinant hepatitis E virus capsid protein
p239(ORF2,aa368-606) which showed good immunogenicity and reactivity,and has been confirmed
to have a simulated structure compared with native viruses. In the present study,p239 was ...
Cited by 4 - Related articles - Cached

 

wjgnet.com [PDF]NS Xia, HJ Yang, J Zhang, CQ Lin, YB … - World Journal of …, 2001 - wjg.wjgnet.com
E-mail: wjg@wjgnet.com www.wjgnet.com ... Copyright © 2001 by The WJG Press ISSN
1007-9327 ... Ning-Shao Xia1, Hai-Jie Yang1, Jun Zhang1, Chang-Qing Lin1, Ying-Bin
Wang1, Juan Wang1, Mei-Yun Zhan2 and MH Ng3 ... 1Key Laboratory of the Ministry of ...
Cited by 4 - Related articles - View as HTML - BL Direct - All 9 versions

 

XIE Xiao-Yan, XIA Ning-Shao - Letters in Biotechnology, 2001 - en.cnki.com.cn
The phenomenon of fluorescence resonance energy transfer(FRET) can be utilized to evaluate
or to detect the distance between macromolecules.Recently,many new material and methods
have been introduced into the use of this phenomenon,which has facilicated the ...
Cited by 3 - Related articles - Cached

 

… -lian, MA Ying, W ZHENG, XIA Ning-shao - Letters in …, 2002 - en.cnki.com.cn
Half-embryo was used as the acceptor of peanut transformation for the first time.Half-embryo
co-culture with Agrobacterium tumefaciens strain EHA105(including plasmid p1301HBsAg)for
five days.Through hygromycin selection,transformed peanuts were obtained.The ...
Cited by 3 - Related articles - Cached

 

… Yun, SY Chun, ZZ Zheng, RLK Ho, ECW Chak, NS Xia, … - Apoptosis, 2007 - Springer
Abstract BH3-only protein Bim is a critical regulator of apoptosis and plays an essential role in
mammalian development, but the characterization of Bim and its iso- forms in hepatocellular
carcinoma (HCC) has not been studied before. Here we investigated the expression, dis- ...
Cited by 3 - Related articles - BL Direct - All 6 versions

 

… -yuan, T Ming, J ZHANG, XIA Ning-shao - Chinese Journal of …, 2007 - en.cnki.com.cn
By using Western blot and immunofluorescence assays,the recombinant HEV capsid protein
p239 was found specifically attached to the HepG2 cell surface and entered to the cytoplasm
with the increase of incubation temperature.Pre-mixture of wild-type HEV with p239 ...
Cited by 2 - Related articles - Cached

 

… SUN Yuan-yuan, J ZHANG, XIA Ning-shao - Chinese Journal of …, 2006 - en.cnki.com.cn
For further understanding the infection mechanism and pathogenesis of hepatitis E
virus(HEV),we screened the protein interacting with HEV virus-like particle(p239) extracted from
HepG2 cells by affinity chromatography,two-dimensional electrophoresis and mass ...
Cited by 2 - Related articles - Cached

 

 

… -tang, K Wei-min, Z Jun, XIA Ning-shao - Chinese Journal of …, 2004 - en.cnki.com.cn
Objective The status of hepatitis E virus infection was under investigation in a general population
based on a novel antibody detection assay.Methods Anti-HEV IgG ELISA based on polymerized
recombinant HEV antigen (E2-IgG ELISA) was used.Results The prevalence of HEV ...
Cited by 2 - Related articles - Cached - All 2 versions

 

… , LIN Jian, LIUR Yi_Xin, W Ying_Bin, XIA … - Chinese Journal of …, 2004 - en.cnki.com.cn
... 3, YAN Qiang,DU Hai-lian,WANG Ying-bin,GE Sheng-xiang,HUANG Shou-jie,JIANG Lang,ZHANG
Jun,XIA Ning-shao(National Institute of Diagnostics and Vaccine Development in Infectious
Disease,Xiamen University,Xiamen 361005,China);Comparison of two diagnostic ...
Cited by 6 - Related articles - Cached

[CITATION] Department of Clinical Laboratory, Beijing Railway General Hospital, Beijing 100038, China; Serological characteristics of a hepatitis E outbreak [J]

… -ying, C Yan, P Geng, S Wei, Z Man, XIA Ning-shao - Chinese Journal of …, 2003
Cited by 2 - Related articles

 

… , H Shou-jie, J Lang, Z Jun, XIA Ning-shao - Chinese Journal of …, 2008 - en.cnki.com.cn
The sensitivity and specificity of two diagnostic reagent to detect the presence of anti-hepatitis
E virus IgG antibodies(E2-IgG and X-IgG) were tested in 460 serum samples taken from population
undergoing an epidemiological investigation of Jiangsu province in 2006 and 72 serum ...
Cited by 2 - Related articles - Cached

 

HE Zhiqiang, G Shengxiang, XIA … - Chinese Journal of …, 2002 - en.cnki.com.cn
... 1, WU Ting,OU Shan-hai,CHENG Tong,HE Shui-zhen,WU Xiao-lu,ZHENG Zhou,ZHANG
Jun,XIA Ning-shao~*(The Research Center for Medical Molecular Virology of Fujian
Province,Xiamen University,Xiamen 361005,China);Immune Response Induced by Recombinant ...
Cited by 5 - Related articles - Cached - BL Direct

 

QU Yong-gang, ZHU Guang-ze, JIN … - Chinese Journal of …, 2008 - en.cnki.com.cn
... 7, YAN Qiang,DU Hai-lian,WANG Ying-bin,GE Sheng-xiang,HUANG Shou-jie,JIANG Lang,ZHANG
Jun,XIA Ning-shao(National Institute of Diagnostics and Vaccine Development in Infectious
Disease,Xiamen University,Xiamen 361005,China);Comparison of two diagnostic ...
Cited by 4 - Related articles - Cached

 

QIN Ai_jian, S Hong_xia, Q Kun, LIU … - Chinese Journal of …, 2003 - en.cnki.com.cn
... 5, CHEN Yi-xin~1,LUO Hai-feng~1,GE Sheng-xiang~1,GUO Yong-li~1,PENG Geng~2, WANG
Jia~3,CHEN Hong-lin~(3,4),ZHANG Jun~1,GUAN Yi~(3,4),XIA Ning-shao~1(1.The Key Laboratory
of Education Minister for Cell Biology and Tumor Cell Engineering of Xiamen ...
Cited by 6 - Related articles - Cached

 

… Yuan-yuan, T Ming, Z Jun, XIA Ning-shao - Journal of Microbes …, 2007 - en.cnki.com.cn
Objective To further investigate the interaction between recombinant hepatitis E virus (HEV) capsid
protein p239 and Grp78/Bip and the role of Grp78/Bip in HEV penetration.Methods We utilized
pull-down, immunoprecipitation and antibody blocking assays to examine the interaction ...
Cited by 1 - Related articles - Cached - All 2 versions

 

 



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