早就注意过这个文献，对这个研究本身并没有兴趣，只是对这个研究的对象有兴趣，氰化钠是非常毒的物质，大概很少有人想到这个东西曾被用于治疗疾病的研究。但不知道为什么现在没有这个方面的研究了。

Radiation Protection by Cyanide of both Rats and Mice

 

Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires.

MANY investigators have found^1–4 that the rat, unlike the mouse, is afforded little or no protection to irradiation damage by the prior administration of cyanide salts. In all their experiments, a limited dose-range of cyanide was tested. The frequently cited results of Dowdy et al. ¹, for example, were obtained using a single dose (3 mg/kg) of sodium cyanide. A recent theory⁵ states that compounds such as cyanide and azide owe their radiobiological action to the property of stabilization of cuprous (Cu I) ion involved in oxidative processes. The proposal suggests that the dose required to achieve protection would be sharply defined and, if not limited by chemical toxicity of cyanide, it should be possible to demonstrate protection in the rat using the proper dose. Accordingly, survival was compared in rats and mice given a wide range of doses of sodium cyanide prior to X-irradiation.

1. Dowdy, A. H. , Bennett, L. R. , and Chastain, S. M. , Radiology, 55, 879 (1950). | PubMed | ISI | ChemPort |
2. Patt, H. M. , Physiol. Rev., 33, 35 (1953). | PubMed | ISI | ChemPort |
3. Yakovlev, V. G. , and Ivanov, I. I. , Meditsinskaii Radiologia, 3, 14 (1958). | ChemPort |
4. Bacq, Z. M. , and Alexander, P. , Fundamentals of Radiobiology (Pergamon Press, New York, 1961).
5. Schubert, J. , Rad. Res., 14, 499 (1961).
6. Sollman, T. , A Manual of Pharmacology (W. B. Saunders Co., Philadelphia, 1957).
7. Hogeboom, G. H. , and Schneider, W. C. , J. Biol. Chem., 194, 513 (1952). | PubMed | ISI | ChemPort |
8. Felsenfeld, G. , Arch. Biochem. and Biophys., 87, 247 (1960). | Article | ISI | ChemPort |
9. Needham, A. E. , Nature, 189, 308 (1961). | Article | PubMed | ISI | ChemPort |

 

JACK SCHUBERT & JOAN FRIED MARKLEY

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