杨焕明（Huanming Yang）
教授，所长，丹麦哥本哈根大学博士
电话：（010）80494969
E-mail: yanghm@genomics.org.cn

研究方向:

??杨焕明教授一直从事基因组科学的研究。杨焕明领导华大中心经过艰苦的拼搏，在世界上首次利用全基因组“霰弹法”策略对大型植物基因组进行测序，独立完成了超级杂交水稻父本籼稻“9311”基因组（大小约为4.6亿个碱基对）的“工作框架图”。该项目的完成，建立和完善了基因组学、生物信息学和蛋白质组学研究的多个技术平台，其水平与发达国家齐步，使我国成为继美国之后的第二个具有全面测定和分析大型全基因组能力的国家，而且从无到有地开发了重复序列识别及注释系统，并率先公布了数据库，促进了“国际联盟”的工作进程，在国际上产生了巨大而深远的影响。

??尤其在抗击非典行动中，带领年轻人团队，同舟共济，团结一心，在SARS冠状病毒的基因组研究及建立诊断方法上又做出了贡献，使我国的基因组研究走向了世界，得到了国内外同行与有关部门的肯定。

??杨教授及其团队（“所承担的人类基因组、水稻基因组以及家猪、家鸡、家蚕基因组等重大项目使我国的基因组研究得以跻身于世界前沿。

主要科研成果:

??杨焕明教授一直从事基因组科学的研究。他主持完成的 “人类基因组计划—中国卷”使中国成为这一被称为“二十世纪登月计划”的宏伟项目的成员国，得到了各国领导人和国际科学界的高度赞扬。杨焕明教授及其团队（“华大基因”）所承担的人类基因组、水稻基因组以及家猪、家鸡、家蚕基因组等重大项目使我国的基因组研究得以跻身于世界前沿。2003年，“华大基因”又在水稻基因组完成图、家蚕基因组“框架图”的绘制以及SARS冠状病毒的基因组研究及建立诊断方法都做出了新的成绩。杨焕明教授还特别关注基因组研究的社会影响和基因知识的普及。

学术职务:

近期主要论文论著:

1. J. Yu, J. Wang, W. Lin, S. Li, H. Li, J. Zhou, P. Ni, W. Dong, S. Hu, C. Zeng, … G.K. Wong, H. Yang. The genomes of Oryza sativa: A history of duplications. PLoS Biology. 3:e38(0001-0016), Feb. 2005.
2. Jing Wang, Ximiao He, Jue Ruan, Mingtao Dai, Jie Chen, Yong Zhang,Yafeng Hu, Chen Ye, Shengting Li, Lijuan Cong, Lin Fang, Songgang Li, Jian Wang, David W. Burt, Gane Ka-Shu Wong, Jun Yu, Huanming Yang and Jun Wang. ChickVD: a sequence variation database for the chicken genome. Nucleic Acids Research. 33: D438–D441, 2005.
3. Jing Wang, Qingyou Xia, Ximiao He, Mingtao Dai, Jue Ruan, Jie Chen, Guo Yu, Haifeng Yuan, Yafeng Hu, Ruiqiang Li, Tao Feng, Chen Ye, Cheng Lu, Jun Wang, Songgang Li, Gane Ka-Shu Wong, Huanming Yang, Jian Wang, Zhonghuai Xiang, Zeyang Zhou and Jun Yu, SilkDB: a knowledgebase for silkworm biology and genomics. Nucleic Acids Research. 33: D399–D402, 2005.
4. Zongzhong Tong, Dongsheng Zhou, Yajun Song, Jian Wang, Jun Yu, Peitang Huang, Huanming Yang, and Ruifu Yang. Genetic variations in pgm locus among natural isolates of Yersinia pestis. The Journal of General and Applied Microbiology. 5, 2005 (In press).
5. Zongzhong Tong, Dongsheng Zhou, Yajun Song, …Jun Yu, Jian Wang, Peitang Huang, Huanming Yang, and Ruifu Yang. Pseudogene accumulation might promote the adaptive microevolution of Yersinia pestis. Journal of Medical Microbiology. 54: 259-268, 2005.
6. Skjoedt, Gane Ka-Shu Wong, Jun Wang, Bin Liu, Jian Wang, Jun Yu, Huanming Yang, Mikhail Nefedov, Maxim Koriabine, Pieter J. deJong. Sequence and comparative analysis of the chicken genome provide unique perspectives on vertebrate evolution. Nature. 432: 695-716, 2004.
7. International Human Genome Sequencing Consortium (Beijing Genomics Institute, Yang as the Coordinator-in-China). Finishing the euchromatic sequence of the human genome. Nature. 431:931-945, 2004.
8. Qingyou Xia, Zeyang Zhou, ……Jian Wang, Gane Ka-Shu Wong, Huanming Yang. A draft sequence for the genome of the domesticated silkworm (Bombyx mori). Science. 306:1937-1940, 2004.
9. International HapMap Consortium (Beijing Genomics Institute, Yang as the Coordinator-in-China). Integrating Ethics and Science in the International HapMap project. Nature Reviews Genetics. 5: 467-475, 2004.
10. Wenming Zhao, Jing Wang, Ximiao He, Yongzhi Jiao, Mingtao Dai, Shulin Wei, Jian Fu, Chen Ye, Xiaoyu Ren, Yong Zhang, Peixiang Ni, Jianguo Zhang, Songgang Li, Jian Wang, Gane Ka-Shu Wong, Hongyu Zhao, Jun Yu, Huangming Yang, Jun Wang. BGI-RIS: an integrated information resource and comparative analysis workbench for rice genomics. Nucleic Acids Research. 32: D377-D382, 2004.
11. Jiabin Tang, Hong’ai Xia, Mengliang Cao, Xiuqing Zhang, Wanyong Zeng, Songnian Hu, Wei Tong, Jun Wang, Jian Wang, Jun Yu, Huanming Yang and Lihuang Zhu. A comparison of rice chloroplast genomes. Plant Physiology, 135:412-20, 2004.
12. Yajun Song, Zongzhong Tong, Jin Wang, Li Wang, Zhaobiao Guo, Yanpin Han, Jianguo Zhang, Decui Pei, Dongsheng Zhou, Haiou Qin, Xin Pang, Yujun Han, Junhui Zhai, Min Li, Baizhong Cui, Zhizhen Qi, Lixia Jin, Ruixia Dar, Feng Chen, Shengting Li, Chen Ye, Zongmin Du, Wei Lin, Jun Wang, Jun Yu, Huanming Yang, Jian Wang, Peitang Huang, Ruifu Yang. Complete genome sequence of Yersinia pestis 91001, an isolate avirulent to humans. DNA Reserach. 11:179-197, 2004.
13. Li Y, Luo C, Li W, Xu Z, Zeng C, Bi S, Yu J, Wu J, Yang H. Structure-based preliminary analysis of immunity and virulence of SARS coronavirus. Viral Immunology. 17:528-34, 2004..
14. International HapMap Consortium (Beijing Genomics Institute, Yang as the Coordinator-in-China). The international HapMap project. Nature. 426: 789-796, 2003.
15. Wang Jian, Li Wei, Xu Zuyuan, Li Yan, Wu Qingfa, Lin Wei, Cheng Weijun, Tang Lin, Deng Yajun, Han Yujun, Li Changfeng,...and Yang Huanming, A complete sequence and comparative analysis of a SARS-associated virus(Isolate BJ01), Chinese Science Bulletin. 48:941-948, 2003.
16. Jingqiang Wang, Jie Wen, Jingxiang Li, Jianning Yin, Qingyu Zhu, Hao Wang, Yongkui Yang, E’de Qin, Bo You, Wei Li, Xiaolei Li, Shengyong Huang, Ruifu Yang, Xumin Zhang, Ling Yang, Ting Zhang, Ye Yin, Xiaodai Cui, Xiangjun Tang, Luoping Wang, Bo He, Lianhua Ma, Tingting Lei, Changqing Zeng, Jianqiu Fang, Jun Yu, Jian Wang, Huanming Yang, Matthew B West, Aruni Bhatnagar, Youyong Lu, Ningzhi Xu, Siqi Liu. Assessment of immunoreactive synthetic peptides from the structural proteins of SARS-coronavirus. Clinical Chemistry. 49: 1989-1996, 2003.
17. Jun Yu, Songnian Hu, Jun Wang, Gane Ka-Shu Wong,…. Jian Wang, Lihuang Zhu, Longping Yuan, Huanming Yang. A draft sequence of the rice (Oryza sativa ssp. indica) genome. Science. 296: 79-92, 2002.
18. Jun Wang, Gene Ka-Shu Wong, Peixiang Ni, Yujun Han, Xiangang Huang, Jianguo Zhang, Chen Ye, Yong Zhang, Jianfei Hu, Kunlin Zhang, Xin Xu, Lijuan Cong, Hong Lu, Xide Ren, Xiaoyu Ren, Jun He, Lin Tao, Douglas A. Passey, Jian Wang, Huangming Yang, Jun Yu, and Songgang Li. RePS: A sequence assembler that masks exact repeats identified from the shotgun data. Genome Research. 12:824-831, 2002.
19. Qiyu Bao, Yuqing Tian, Wei Li, Zuyuan Xu, Zhenyu Xuan, Songnian Hu, Wei Dong, Jian Yang, Yanjiong Chen, Yanfen Xue, Yi Xu, Xiaoqin Lai, Li Huang, Xiuzhu Dong, Yanhe Ma, Lunjiang Ling, Huarong Tan, Runsheng Chen, Jian Wang, Jun Yu, and Huanming Yang. A Complete Sequence of the T. tengcongensis Genome. Genome Research. 12:689-700, 2002.
20. International Human Genome Sequencing Consortium (Beijing Genomics Institute, Yang as the Coordinator-in-China). Initial sequencing and analysis of the human genome. Nature, 409: 860-921, 2001.
21. Jun Yu, Songnian Hu, Jun Wang,….. Lihuang Zhu, Longping Yuan, Huanming Yang. A draft sequence of the rice (Oryza sativa ssp. indica) genome. Chinese Science Bulletin, 46:1937-1942, 2001.