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标题:[转载]Publish or perish in China |
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浏览:137 评论:0 |
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The pressure to rack up publications in high-impact journals could encourage misconduct, some say.
The latest in a string of high-profile academic fraud cases in China underscores the problems of an academic-evaluation system that places disproportionate emphasis on publications, critics say. Editors at the UK-based journal Acta Crystallographica Section E last month retracted 70 published crystal structures that they allege are fabrications by researchers at Jinggangshan University in Jiangxi province. Further retractions, the editors say, are likely.
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本文引用地址:http://www.sciencenet.cn/m/user_content.aspx?id=291761 |
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标题:Scientific fraud: action needed in China |
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浏览:278 评论:1 |
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看完后无地自容! On Dec 19, 2009, editors at Acta Crystallographica Section Ealerted the scientific community to a disgraceful pattern of fraud involving papers they had published in 2007. At least 70 false crystal structures were reported—mainly from two groups led by Hua Zhong and Tao Liu, both at Jinggangshan University, Jian, China. All authors have now agreed to retraction of 41 papers published by Zhong and 29 by Liu. It is rather surprising that wrongdoing on such a scale evaded detection during peer review and, considering that crystal structures are deposited in public databases upon publication, that the truth has been uncovered so slowly.
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本文引用地址:http://www.sciencenet.cn/m/user_content.aspx?id=288678 |
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标题:Quantifying western blots without expensive commercial quantification software. |
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浏览:300 评论:0 |
Quantifying western blots without expensive commercial quantification software. Comparing the intensity of bands on a Western blot can be done in a number of ways using software that is commonly found on lab computers or freely available for download. The following document outlines some of those methods. For a long time, the de-facto standard for analysis in labs that didn't want to spring for multi-thousand $$ commercial densitometry software was Adobe Photoshop or one of the competing photo editing programs. All you really need in a program is a freehand selection tool and a way to measure the mean gray value inside the selection. We'll start with Adobe Photoshop as an example (you can find many references in the literature that include phrases such as "densitometry was carried out in Photoshop" in the methods section).
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本文引用地址:http://www.sciencenet.cn/m/user_content.aspx?id=272858 |
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标题:如何写一篇高质量的ROC分析文章 |
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浏览:413 评论:0 |
一, ROC分析的基础。 检验医学的论文大题可以分为两类,一类是方法学论文,只要是质量控制,方法学评价,对比等,另一类就是实验室指标的应用,使用指标诊断疾病,观察指标与疾病预后和病理分期的关系等。ROC分析的文章就属于后者,其目的主要是评价某指标对某种疾病的诊断意义。如“AFP在肝癌诊断中的作用”,“CEA,NSE联合诊断肺癌”等。 众所周知,用单一实验室指标去诊断疾病,单独提高敏感性必然会降低特异性,反之亦然;换句话说,减少误诊必然增加漏诊。比如,某医师欲采用AFP诊断肝癌,该医师制定的诊断标准是AFP大于10mmol/L,显然按照此标准诊断肝癌,具有很高的敏感性,是不会漏诊肝癌的的,因为几乎所有的肝癌患者AFP都大于10 mmol/L。但是另一方面,依据此标准却容易造成误诊,因为AFP大于10 mmol/L的病人中,除了肝癌还有肝炎和肝硬化等肝脏疾病。该医师意识到这个问题后,将肝癌诊断标准从10 mmol/L提高到1000 mmol/L,并以此作为诊断肝癌的标准,显然,以此为标准,自然是不会误诊病人,因为AFP大于1000 mmol/L几乎就可以肯定是肝癌了。但是另一方面,却增加了漏诊,因为不是所有的肝癌患者AFP都大于1000 mmol/L的。由此可见,漏诊和误诊之间是相互矛盾的,减少误诊必然以增加漏诊为代价,减少漏诊又必然以增加误诊为代价,敏感性与特异性始终是鱼与熊掌不可兼得的矛盾。
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本文引用地址:http://www.sciencenet.cn/m/user_content.aspx?id=248226 |
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标题:注定要守望一生! |
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浏览:352 评论:1 |
守着千年的沧桑,月升日落,朝朝暮暮,只因为思念太美。望尽天涯,过帆千千,盼也悠悠,恨也悠悠,只因为等待太久。
不郧嵋壮信担不曾轻言爱的深度。此情可待成追忆,只是当时已惘然!如今又到黄昏醉雨时,只是茫茫海上哪一只帆是你?回首梦儿依旧,人儿远去。望尽天涯流云处,终究还是魂也依依,梦也依依!
也运剂肯嗨加屑付罚也曾算计等待有几朝。思来量去,欲舍又难抛!算来计去,等待也无悔!
当沧海已变成桑田5笨奁的眼眸变成黑夜的星星,孤独的我已渐渐化为一块情人石,永远等待着你的帆归来!
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本文引用地址:http://www.sciencenet.cn/m/user_content.aspx?id=247478 |
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标题:今夜,我是如此的想你! |
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浏览:413 评论:0 |
今夜,我是如此的想你! 再唯美的文字,也无法阐述的清我心中思念之情!深夜,以一种寂寞的姿势坐着,一动不动。 以为新的生活开始不会再想起过去的伤痛,可暗夜里是什么滑落,那么湿。K 手心手背都是凉,连擦拭都显得那么牵强。这个午夜是真的冷纵然把门窗关个严实,纵然把电暖器开到最大,纵然怀抱着暖宝,寒冷,仍是无孔不入,那深入骨髓的冰凉无处不在,心仍是痛了。蜷缩在黑夜的角落。我知道过去在我心里还没有过去,暗夜里把伤口打开,仍会看见血痕,那是你留下的印迹。独自行在没有你的夜,关上曾经开启的心扉,拒绝所有的援手,阻止所有友善的好奇的目光,也阻止爱情入侵。寂寞像一根绳子,勒得我无法呼吸。我是那么坚强的男人,也是多么需要温暖的男人?...
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本文引用地址:http://www.sciencenet.cn/m/user_content.aspx?id=247218 |
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